• Why the Windows 95 setup process used 3 different OS’s.

    I probably installed Windows 95 hundreds of times over my career and never knew this. Makes sense once you know.

    Why Win 95 uses three different operating systems

    Monday November 18, 2024
  • Business

    ,

    Internet

    ,

    Technology

    ,

    Cyber

    Time to Give AI a Rest

    Like a lot of people, I too am sick of AI in everything. It’s a useful tool that’s degenerated into nothing more than every company in the world trying to jam the LLM down our thoughts as the next big thing (aka the game change).

    I am not alone. See here

    Friday September 27, 2024
  • Science

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    Medicine

    Cause of Lupus Found

    Very impressive work by a team of doctors finding cause of the disease Lupus.

    We’ve identified a fundamental imbalance in the immune responses that patients with lupus make, and we’ve defined specific mediators that can correct this imbalance to dampen the pathologic autoimmune response,” said co-corresponding author Deepak Rao, MD, PhD, an assistant professor of medicine at Harvard Medical School and a rheumatologist at Brigham and Women’s Hospital and co-director of its Center for Cellular Profiling. 

     

    In the study, the scientists reported a new pathway that drives disease in lupus. There are disease-associated changes in multiple molecules in the blood of patients with lupus. Ultimately, these changes lead to insufficient activation of a pathway controlled by the aryl hydrocarbon receptor (AHR), which regulates cells’ response to environmental pollutants, bacteria or metabolites. Insufficient activation of AHR results in too many disease-promoting immune cells, called the T peripheral helper cells, that promote the production of disease-causing autoantibodies.

     

    To show this discovery can be leveraged for treatments, the investigators returned the aryl hydrocarbon receptor-activating molecules to blood samples from lupus patients. This seemed to reprogram these lupus-causing cells into a cell called a Th22 cell that may promote wound healing from the damage caused by this autoimmune disease.

    Obvious caveats. Any type of drugs to reverse Lupus are a long ways off. What is great is that they landed in Nature which may spark more interest in this area of study. 

    Source: Northwestern Medicine

    Thursday July 11, 2024
  • Science

    ,

    Medicine

    New Drug for Alzheimer's Nears Wider Market Approval

    A bit of good news for a Friday

    On Monday, the panel unanimously voted that the medicine, developed by Eli Lilly and known as donanemab, appears to be an effective treatment for certain Alzheimer’s patients. The experts also concluded, by an 11-0 vote, that the drug’s benefits outweigh its risks, despite some safety concerns.

    Source: Biopharmadive

    Friday June 21, 2024
  • Science

    ,

    Medicine

    New Way to Grow Human Liver Being Trialed

    Well this is just down right extraordinary. It would be amazing if this works!

    The approach is unusual: researchers injected healthy liver cells from a donor into a lymph node in the upper abdomen of the person with liver failure. The idea is that in several months, the cells will multiply and take over the lymph node to form a structure that can perform the blood-filtering duties of the person’s failing liver.

    Source: Max Kozlov writing for Nature

    Wednesday April 3, 2024
  • Science Fiction

    Vernor Vinge has passed away

    One of my favorite authors has moved on to what’s next (honestly nobody knows).

    A Fire Upon the Deep remains one of my favorite stories written by him. 

    He will be missed on this side for sure.

    Vernor Vinge (1944-2024)

    Thursday March 21, 2024
  • Medicine

    Whats in a Copy?

    Well this certainly does not strike confidence in medical device development. I would think this would be a fixable issue but the fact it’s still present certainly seems like it's being exploited at some level.

    Source:  William Edmisten Blog

    The Hacker News comments are also worth a read: Hacker News

    Monday March 11, 2024
  • Technology

    ,

    Gaming

    And Now DOOM....running on a Toothbrush

    Well the train keeps chugging along the “what exactly can we get Doom to run on next tracks…."

    Doom Running no a Toothbrush

    Thursday February 29, 2024
  • Technology

    Battery Passports

    While I doubt this would ever take off in the US it’s interesting to see.

    The digital documents will be linked to the VIN and a QR code that, when scanned with a digital device, will reveal detailed information about the sources and nature of the raw materials prior to manufacturing, along with post-manufacturing details, such as capacity and condition

    Source: Autocar

    Wednesday January 17, 2024
  • Science

    Insight into Lupus

    Researchers have found what can cause Lupus in children. From the article:

    Sometimes a single mutation in our genetic make-up is enough to cause disease. This is also the case with the autoimmune disease lupus. Lupus causes severe inflammation throughout the body and can have a serious impact on the lives of those affected. Researchers at the Max Planck Institute for Infection Biology in Berlin have now discovered a mechanism that can trigger lupus in children. This mechanism regulates the amount of a specific immune receptor that normally recognizes the genetic material of pathogens. If this mechanism is disrupted, receptors accumulate in the immune cells leading to the recognition of the body's own genetic material. As a result, the immune system turns against its own body and causes the systemic inflammation of lupus.

    Source: Max-Plance-Gesellschaft

    Sunday January 14, 2024
  • Science

    Finally - What's in Pee

    Our long national nightmare is over. Researchers have determined an enzyme is responsible for making our urine yellow.

    From the article:

    Gut microbes encode the enzyme bilirubin reductase that converts bilirubin into a colorless byproduct called urobilinogen," explained Hall, who has a joint appointment in the University of Maryland Institute for Advanced Computer Studies. "Urobilinogen then spontaneously degrades into a molecule called urobilin, which is responsible for the yellow color we are all familiar with.

    Source: Phys.org

    Friday January 5, 2024
  • Science

    Cause of Fatigue in Long Covid Patients Found

    Well this is some good news. Via the article:

    We saw various abnormalities in the muscle tissue of the patients. At the cellular level, we saw that the mitochondria of the muscle, also known as the energy factories of the cell, function less well and that they produce less energy," says Rob Wüst, Assistant Professor at Department of Human Movement Sciences at the VU University. "So, the cause of the fatigue is really biological. The brain needs energy to think. Muscles need energy to move. This discovery means we can now start to research an appropriate treatment for those with long-COVID

    Source: Amsterdam UMC

    Thursday January 4, 2024
  • Health

    Phenylephrine determined not to work

    Interesting to see this kind of science. A rare win in todays medical landscape for consumers.

    Schering-Plough, the maker of Claritin D (loratadine and pseudoephedrine), was already studying phenylephrine as an alternative oral decongestant. In addition to funding two studies that found phenylephrine was no better than placebo when patients with seasonal allergies were exposed to allergens (grass and ragweed) in a controlled chamber, they funded additional research.

    Source: Scientific American

    Friday December 22, 2023
  • Science Fiction

    Space 1999 - The Catacombs - Comprehensive guides to Space 1999

    Space1999

     

    Whilst tunneling on the Internets (a series of tubes), I came across The Catacombs - Comprehensive guides to Space 1999. A breakout of all things Space 1999. I loved the series as a kid. I have even purchased the remastered BlueRay versions. If you have not checked it out I recommend it. Its campy and worth your time if you like science fiction.

    Source: The Catacombs - Comprehensive guides to Space 1999

    Friday November 3, 2023
  • Business

    The Death of Microwaves and the Instapot

    Some very interesting facts on why microwaves are terrible these days along with the death of the maker of InstaPots.

    Source: Moth.Monster

    Friday October 27, 2023
  • Technology

    Insanity of Airbnb

    Now I realize there are always two sides to every story and don’t believe everything you read on the internet. With that said I have read more and more of these stories.

    If this is even remotely true, this is utter and totally insanity and should be a huge red flag for Airbnb would be hosts.

    Here's the story of how I ended up pregnant and homeless and in over $300,000 of debt after Airbnb guests flooded my home

    Source: Coach Erika on X 

    Friday October 20, 2023
  • Movies

    Graham Chapman's Eulogy by Sir John Cleese

    Came across this in my digital travels. It's stuff like this that will forever make them legends.

    Wednesday October 4, 2023
  • Science

    Nobel Prize in medicine awarded to scientists who laid foundation for messenger RNA vaccines

    WELL deserved I might add.

    Source: Washington Post

    Monday October 2, 2023
  • Cyber

    Sony Systems Compromised

    Appearing on Kotaku, Sony systems have been supposedly breach by a ransomware gang called Ransomed.vc. The gang has indicated they will be selling the compromised data.

    “We have successfully [compromised] all of [Sony’s] systems,” Ransomed.vc proclaimed. “We won’t ransom them! We will sell the data. Due to Sony not wanting to pay. DATA IS FOR SALE. WE ARE SELLING IT.”

    Another day of digital life….

    Source: Kotaku

    Tuesday September 26, 2023
  • Technology

    Ziply Fiber and the MTU Universe

    I wanted to put this out there in case some other poor savage goes down this road. Plugging a Ziply fiber connection into a EdgeRouter 4 will most likely see you dropping packets randomly. This is due to the MTU size needing to be adjusted. In my case, the default value in use was 1500. I needed to set it to 1492 to eliminate the issue. I screwed around with numerous equipment swap outs and resets trying to figure out what was going on. I have had to set the MTU for an ISP exactly once in my life (this being it) and I have consulted for a great many years. I have a redundant Internet connection. The failures would see me ping ponging between connections (driving me insane in the process). The fix:

    SSH into your router (or CLI in the GUI) and do the following:

    configure
    set interfaces ethernet ethX pppoe X mtu 1492
    set firewall options mss-clamp mss 1452
    set firewall options mss-clamp interface-type all
    commit;save
    

    Reboot your router and you should be good. You can also do this in the GUI. Select your WAN interface (via DASHBOARD tab) and click config. You will see the MTU value there. Next, you can go to config tree and then firewall / options / mss-clamp : Enable IPv4 TCP MSS clamping for specified interface types. Set the value of 1452. Save and reboot.

    Hope this helps you!

    Friday September 15, 2023
  • Technology

    Aardvark'd: The Fog Creek Documentary, 18 Years Later

    Stumbled across this on the internetz. Interesting documentary on Fog Creek software. Well worth the view.

    Source: Michael Lynch Website

    Friday September 8, 2023
  • Science

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    Nature

    Beetle grows ‘termite’ on back to steal food

    Just when I thought nature could not get crazier, she proves me wrong yet again.

    Richard Pallardy writing for Science.org:

    The new beetle species (Austrospirachtha carrijoi)—found beneath the soil in Australia’s Northern Territory—emulates a termite by enlarging its abdomen, a phenomenon known as physogastry. Evolution has reshaped this body part into a highly realistic replica of a termite (as seen above), head and all, which rides on top of the rest of the beetle’s body. The beetle’s real, much smaller head peeks out from beneath its termite disguise, the authors report this month in the journal Zootaxa.

    Source: Science.org

    Thursday September 7, 2023
  • Entertainment

    ,

    Gaming

    The Return of Alan Wake

    The original Alan Wake was released in 2010. Although the game generally got good reviews, I could never get into it much. Remedy, the makers of Alan Wake, also make Control, which I much preferred. The game authors have indicated that Alan Wake is in the same universe as Control and there is even an expansion for Control that included Alan Wake.

    Remedy is getting ready for the coming release of a sequel to Alan Wake. Judging from the video for the next-generation console graphics it appears to be highly polished. I may just have to come back to this title.


    Tuesday August 29, 2023
  • Entertainment

    Why Cartoon Characters Wear Gloves

    Apparently there are several answers. I had zero clue this was a thing.



    Source: Vox

    Tuesday August 29, 2023
  • Science

    Added to the Growing List of "Nope"

    Well I shall not lie, this is disturbing.

    It was a fairly regular day on the ward for Canberra hospital infectious diseases physician Dr Sanjaya Senanayake, until a neurosurgeon colleague called him and said: “Oh my God, you wouldn’t believe what I just found in this lady’s brain – and it’s alive and wriggling.”

    The neurosurgeon, Dr Hari Priya Bandi, had pulled an 8cm-long parasitic roundworm from her patient, prompting her to call on Senanayake and other hospital colleagues for advice about what to do next.

     

    Source: The Guardian

    Monday August 28, 2023